The understanding of Lipoedema has evolved significantly and what was once considered a simple adipose tissue (fat) distribution disorder, recent research identifies it as a systemic inflammatory disease where the gut microbiome acts as a primary modulator of inflammation the adipose tissue microenvironment.

Lipoedema (LIE-poh-dee-muh) is a chronic inflammatory condition of excess adipose tissue (fat) affecting primarily women. It goes beyond simply having trouble losing weight in certain areas, and is a complex interplay between fat tissue, connective tissue, and the lymphatic system, leading to a painful and often frustrating imbalance of fat distribution.